Experience
2019 - 2022 Medipol University
2010 Private Nisa Hospital
2008 - 2010 Kaman State Hospital
Education
2008
Istanbul University Cerrahpaşa Faculty of Medicine, Obstetrics and Gynecology
2002
Istanbul University, Istanbul Faculty of Medicine
Specializations
Arthroscopic Debridement and Microfracture Surgery
Arthroscopic Meniscectomy Surgery
Arthroscopic Anterior Cruciate Ligament Reconstruction
Arthroplasty (Total Joint Prosthesis) Surgery
Knee, Shoulder, Hip Replacement Surgery
Hallux Valgus Surgery (Toe Deformity)
Trauma Surgery
Soft Tissue Tumoral Mass Excision
Experience
Maraş Budaklı Health Center 1993
İnönü University Research Hospital 1994
Kartal Training and Research Hospital 1995-2000
Private Gül Medicine Ensar Hospital 2002
Gebze Central Hospital 2002-2010
Private Oran Cerrah Medical Center 2010-2018
Hospital Park 2019-2021
Education
Cerrahpaşa Faculty of Medicine
Experience
2016 - 2019 Private Gebze Konak Hospital
2014 - 2015 Private Medicana Camlica Hospital
2013 - 2014 Private Batman Hospital
2011 - 2013 Batman Regional State Hospital
Uskudar University
Gazi University Faculty of Medicine
Education
2011 Bezmialem Vakıf University Faculty of Medicine, Physical Medicine and Rehabilitation
2005 Marmara University, Faculty of Medicine in English
Experience
2018
Private Istanbul Medipol Hospital
2018
Medipol University Camlica Hospital
2018
Medipol Camlica Hospital
2013 - 2018
Medipol Mega University Hospital
2011 - 2013
Yuzuncu Yil University Hospital
2010 - 2011
Gulhane Military Medical Academy
2010 - 2013
Yuzuncu Yil University Hospital
2010 - 2011
Gulhane Military Medical Academy
2010 - 2011
Gulhane Military Medical Academy
2010 - 2013
Yuzuncu Yil University Faculty of Medicine
2009
University of Toronto SickKids Hospital
2004 - 2008
Private Van-Etfal Pediatric Diseases
1999 - 2004
Yuzuncu Yil University Hospital
Education
2010
Yuzuncu Yil University, Pediatric Nephrology
2004
Yuzuncu Yil University, Pediatrics
1998
Ege University, Faculty of Medicine
Viral hepatitis A, B, C, D
Cirrhosis
Autoimmune liver diseases
Fatty liver
Diseases of the stomach and intestines
Diseases of the pancreas
Services in the field of biological medicine:
Treatment of various drug-induced liver poisonings, viral hepatitis (hepatitis B, hepatitis C), hepatosis, hepatosterosis, autoimmune hepatitis.
EDUCATION: Azerbaijan Medical University
EXPERIENCE:
2009-2010 General practitioner in a private clinic.
Clinic of biological medicine since 2011.
TRAINING AND MEMBERSHIP:
In 2013-2014, internship on viral hepatitis at the Department of Microbiology and Infection, as well as at the Department of Gastroenterology, Faculty of Medicine, Ege University, Turkey.
Ankara Hacettepe Hospital
Medical Interests:
• Brain, cerebellum, spine, and spinal cord tumor surgeries in adults and children
• Pediatric Neurosurgery Surgeries (Hydrocephalus, Tethered Cord, Diastematomyelia, Encephalocele, Meningocele-Meningomyelocele, Dermal Sinus Tract Excision, Craniosynostosis)
• Spine Surgery (Lumbar and Cervical Disc Herniation, Spondylolisthesis, Spinal Stenosis, Stabilization for Spinal Fractures, Vertebroplasty-Kyphoplasty Surgeries, Kyphosis Surgery)
• Deep Brain Stimulation Surgery for Parkinson's Disease, Essential Tremor, and Dystonia
• Vagal Nerve Stimulation Surgery (Epilepsy Surgery) • Spinal Cord Stimulation Surgery (Spinal Cord Pain Stimulator)
• Surgeries for Trigeminal Neuralgia and Hemifacial Spasm
• Baclofen Pump Implantation Surgery (for Severe Spasticity)
• Surgeries for Aneurysms, AVMs, and Cavernomas
Professional Experience Compulsory Service 2014 - 15 District Health Director - Güroymak Community Health Center/BİTLİS Specialization 2015 - 20 Fırat University Faculty of Medicine, Department of Neurosurgery. Work Location 2024 - present Eskişehir City Hospital Neurosurgery Department Education Siirt Ataturk Anatolian High School 2003 - 07 Fırat University Faculty of Medicine 2007 - 13 SCIENTIFIC ARTICLES • 1. Ozturk S, Erol FS, Akgun B, Surme MB, Artas G, Ozercan IH. Intradural Extramedullary Spinal Cavernous Hemangioma Mimicking Neurofibroma in a Patient Diagnosed with Neurofibromatosis Type I. Turkish Journal of Neurosurgery 2016; 26:141-144. • 2. Akgun B, Ozturk S, Taskent I, Surme MB, Erol FS, Yildirim H. Evaluation of Apparent Diffusion Coefficients in the Cerebellar Tonsils and Bulbus in Chiari Type I Malformations: Comparison Before and After Surgery. Turk Neurosurg. 2017 May 7. • 3. Surme MB, Hergünsel OB, Ertugrul B, Kaplan M. Ossifying Chronic Subdural Hematoma. Turkiye Clinicals Journal of Neurology. 2017;12:44-48 • 4. Akgun B, Surme MB, Ozturk S, Erol FS. Spontaneous Spinal Epidural Hematomas: Evaluation of 12 Cases. F.U. Journal of Health Science and Medicine. 2016; 30:107-111. • 5. Surme MB, Hergunsel OB, Akgun B, Kaplan M. Cranioplasty with preoperatively customized Polymethyl-methacrylate by using 3-Dimensional Printed Polyethylene Terephthalate Glycol Mold. J Neurosci Neurol Disord. 2018; 2:052-064. • 6. Bakal U, Poyraz AK, Tartar T, Akdeniz I, Surme MB, Çelik S. A Rare Complication of Ventriculoperitoneal Shunt: Asymptomatic Small Bowel Perforation Istanbul Med J 2019; 20(6): 571-3. • 7. De Lima L, Surme MB, Gessi M, Mastronuzzi A, Miele E, Tamburrini G, Massimi L. Central nervous system high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)—case-based reviews Child's Nervous System ( 2020) 36:1589–1599 • 8. Surme MB, Demir F, Erol D., Kaplan M. Is There A Genetic Relationship Between Acute Lymphoblastic Leukemia And Meningioma ? A Case Report Of 3 Genes Analyzes. Arq Bras Neurocir 2021;00:1–3. • 9. Gurbuz O, Surme MB. The effect of intradiscal percutaneous radiopaque gel ethanol injection on pain in patients with lumbar disc herniation: Our clinical experience. Eskisehir Med. J. 2022; 3(2):130-137. • 10. Arikan E, Surme MB. Evaluation of Clinical and Radiological Findings of Patients Diagnosed with Spontaneous Intracerebral Hematoma. Mevlana Medical Sciences Journal 2 (2), 70-74. ORAL PRESENTATIONS • Hergünsel OB, Ertugrul B, Surme MB, Kaplan M. A Case of Cervicogenic Headache Treated with C1 Posterior Arch Resection. Turkish Journal of Neurosurgery 30th Scientific Congress, 8-12 April 2016, Antalya. • Ozturk S, Erol FS, Akgun B, Surme MB, Artas G, Ozercan İH. Intradural Extramedullary Spinal Cavernous Hemangioma Mimicking Neurofibroma in a Patient Diagnosed with Neurofibromatosis Type I. Turkish Neurosurgery Society 30th Scientific Congress. 8-12 April 2016, Antalya. • Ertugrul B, Surme MB, Ozturk S, Kaplan M. A Case of Sacrococcygeal Teratoma Presenting with Intergluteal Tail. Turkish Neurosurgery Society 30th Scientific Congress. 8-12 April 2016, Antalya. • Akgun B, Surme MB, Ozturk S, Demir F, Okcesiz I, Erol FS. Evaluation of Acute Lumbar Disc Hernias with Thin Section Lumbar MRI. 12th International Turkish Spine Congress, 19-22 April 2017, Antalya. • Akgun B, Ozturk S, Taskent I, Surme MB, Erol FS, Yildirim H. Evaluation of Apparent Diffusion Coefficients in the Cerebellar Tonsils and Bulbus in Chiari Type I Malformations: Comparison Before and After Surgery. XVI. World Congress of Neurosurgery, August 20-25, 2017, Istanbul. • Akgun B, Surme MB, Ozturk S, Erol FS. Spontaneous Spinal Epidural Hematomas: Evaluation of 12 Cases. 12th International Turkish Spine Congress. 19-22 April 2017, Antalya. • Surme MB, Hergunsel OB, Celik S., Kaplan M, Erol FS. Evaluation of Cases with Cervical Spondylomyelopathy who underwent corpectomy - Our Clinical Experience. Turkish Neurosurgery Society 32nd Scientific Congress. 20-24 April 2018, Antalya. • Surme MB, Hergunsel OB, Akgun B, Kaplan M. Repair of Orbitofrontal Defects Using Polymethylmethacrylate Grafts Created by 3D Printer. Turkish Neurosurgery Society 32nd Scientific Congress. 20-24 April 2018, Antalya. C I T A T I O N S • My publications have a total of 40 citations. CERTIFICATES (OTHER) • 1. I received an Academic Incentive Bonus for 1 year in 2017 for my academic publications. • 2. Community Health Center Physicians Education. 14-18 July 2014, Kars. (Turkish public health institution). • 3. V. Turkey Zoonotic Diseases Symposium. 24 October 2015, Erzurum. (EKMUD- Turkish Infectious Diseases Specialization Association and TVHB - Turkish Veterinary Medical Association). • 4. Meaningful Occupation Solutions Together. 15-17 April 2015, Gothenburg/Sweden. (Lifelong Learning Programme). • 5. Certificate of Achievement (Position: District Health Manager) 2015, Güroymak/ Bitlis • (Güroymak District Governorship) • 6. Between 16.03.2019 - 04.04.2019, I performed my military service in Mamak/Ankara and was given a 'Certificate of Appreciation'. CERTIFICATES (NEUROSURGERY) • 1. Intracranial Aneurysms and Vascular Neuroanatomy. 14-15 January 2017, Mersin (TNDer Neuroanatomy and Neurovascular Education Training Group). • 2. XII. International Turkish Spine Congress. 19-22 April 2017, Antalya (Turkish Spine Association). • 3. Certificate of Use of Experimental Animals. 10.12.2018 – 20.12.2018, Elazig (FÜSEM- Fırat University Continuing Education Center). • 4. Turkish Neurosurgery Academy 4th Scientific Conference. 1-4 November 2018, Adana. • 5. Turkish Neurosurgery Society Training Program 6.Semester 1.Module. 28.06.2018- 01.07.2018, Mudanya/Bursa. (Spinal and Peripheral Nerve Surgery Group). • 6. Turkish Neurosurgery Association Training Program 7.Semester 2.Module 27.06.2019 – 30.06.2019, Van. (Spinal and Peripheral Nerve Surgery Group). • 7. Turkish Neurosurgery Association Training Program 8th Term 1st Course 2-5 May 2019, Kayseri. (Pediatric Neurosurgery Teaching and Training Group). • 8. Current Developments in Gamma Knife Radiosurgery. 30.11.2019, Elazig. (Koç University Faculty of Medicine Prof. Dr. Selçuk Peker) • 9. Turkish Neurosurgery Society 25. Spinal Symposium 28-31 October 2021, Çeşme. (Spinal and Peripheral Nerve Surgery Group) • 10. Turkish Neurosurgery Society, 34. Scientific Congress. September 30 - October 3, 2021, Online • 11. Turkish Neurosurgery Association, NOVA 19-22 May, 2022, Kütahya. (Speaker) • 12. Spinal Deformity Correction Maneuvers Course 21 May 2022, Eskişehir. (Speaker) • 13. Turkish Neurosurgery Society, 35. Scientific Congress. 24 – 27 November 2022, Antalya. (Speaker) • 14. Complex Spinal Surgery, February 4, 2023, Eskişehir (Speaker). • 15. I worked as a fellow in the Pediatric Neurosurgery department of Catholica University (Rome/Italy) Agostino Gemelli Hospital between 15.01.2020 and 14.02.2020 for 1 month. ORAL PRESENTATIONS(2) • Surme MB, Ertugrul B, Sen D, Kaplan M. Is There a Genetic Link Between Meningioma and Acute Lymphoblastic Leukemia? A Case Presentation Involving the Analysis of 3 Genes. 33rd Scientific Congress of the Turkish Neurosurgery Congress. April 11-14, 2019, Antalya. • Ozturk S, Surme MB, Gönen M, Yıldırım H, Korkmaz S, Kocabıçak E. Analysis of Perfusion Changes in White and Grey Matter in Parkinson's Patients Treated with Subthalamic Nucleus Deep Brain Stimulation. 34th Scientific Congress of the Turkish Neurosurgery Congress. September 30 - October 3, 2021, Online." • "Surme MB, Ustun ME. Case of Vertebrobasilar Insufficiency Due to Vertebral Artery Dolichoarteriopathy. NOVA 2022, Kütahya." • "Ustun ME, Surme MB. Can vertebrobasilar insufficiency lead to parkinson like symptoms? EANS 2022, Belgrade." • "Ustun ME, Surme MB. Do vertebral artery stenoses have an atherosclerotic origin? EANS 2022, Belgrade." • "Surme MB, Yilmaz AH, Ustun ME. Could Resistant Urinary Incontinence Be Related to Vertebrobasilar Insufficiency? Our Initial Case Experiences. 31st National Urology Congress. October 27-30, 2022, Cyprus." • "Surme MB, Akgün B, Isci M, Baloglu M, Millet H. Evaluation of the Effectiveness of Surgical Approaches to Cervical Spondylotic Myelopathy on Cervical Spinal Canal Diameter and T2 Signal Intensity. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya. • Surme MB, Cosar A, Daltaban IS, Ustun ME. Efficacy of a New Surgical Technique for Carotid Artery * "Surme MB, Arikan E, Baloglu M, Millet H, Ercan S. Analysis of Clinical and Radiological Findings in Cases November 24 – 27, 2022, Antalya. • "Surme MB, Cosar A, Ustun ME. Can Vertebrobasilar Insufficiency Cause Parkinson-like Symptoms? 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya. Diagnosed with Spontaneous Intracerebral Hematoma. 35th Scientific Congress of the Turkish Neurosurgery Congress. Dolichoarteriopathies in Patients with Moderate Hemiparesis due to Cerebrovascular Ischemic Attacks. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya." • "Baloglu M, Millet H, Ercan S, Surme MB, Yayla E. The Effect of MCI-186 on Lipid Peroxidation in Rats with Experimental Traumatic Brain Injury. 35th Scientific Congress of the Turkish Neurosurgery Congress. November 24 – 27, 2022, Antalya." * "Surme MB, Ustun ME. Can Quantitative ElectroCorticoGraphy (ECoG) Be More Valuable Than Non -Quantitative ECoG? A Preliminary Report. Bridging Neurosciences and Neurosurgery: New Frontiers in Intraoperative Neurophysiology. February 2 – 4, 2023, Verona, Italy
Dr. Osman Aktas has been serving as a general surgeon at Ataşehir Avicenna Hospital since 2005. Born in Kayseri in 1960, he graduated with his medical degree from Ankara University in 1983. Following his graduation, he fulfilled his military service in medical units for two years. He completed his general surgery residency at GATA from 1986 to 1990. After specializing in general surgery, He held key positions as head of general surgery departments and chief physician in several prominent military hospitals, including Tatvan, Diyarbakır, Ankara, and Manisa.
Dr. Osman has had a special focus on endoscopic surgery since 1995. He received advanced training in laparoscopic surgery techniques in Germany and has successfully performed a wide range of laparoscopic procedures. His expertise extends to gallbladder surgery, abdominal wall and inguinal hernia repairs, appendicitis, reflux and stomach surgeries, as well as complex cases such as gastrointestinal tumors, intestinal obstructions, and various other intestinal diseases, all managed through minimally invasive methods.
In 2002, Dr. Osman transitioned to the private sector, where he broadened his practice to include modern treatments for anal diseases like hemorrhoids, fistulas, and fissures, utilizing advanced techniques such as laser therapy.
Dr. Osman is also recognized for his significant contributions to oncological surgery. He has a wealth of experience in the surgical treatment of various cancers, including breast and thyroid cancer, where he has implemented new treatment methods that reduce the risk of complications. His surgical expertise spans critical cancer surgeries, such as the Whipple procedure for pancreatic cancer, colorectal cancer resections, gastric cancer, and other complex malignancies. Additionally, his skills in metabolic surgery have led to lasting outcomes for patients suffering from obesity and diabetes, ensuring a better quality of life through sustained weight loss and reduced risk of diabetes.
With his vast experience and advanced skills in both laparoscopic and cancer surgeries, Dr. Osman remains at the forefront of surgical excellence, offering innovative and comprehensive care to all his patients.
Prof. Çağatay Öztürk is an experienced orthopedic and spine surgeon specializing in scoliosis and spine surgery. He holds a medical degree from the Hacettepe University and a specialization in orthopedics and traumatology from the Uludağ University. He is the Head of the Spinal Surgery Department in Liv Hospital and is a member of several professional organizations. He has published over 100 articles in international editions.
Dr. Mustafa Kilic is a skilled neurosurgeon with expertise in neuromodulation. He performs Deep Brain Stimulation, Spinal Cord Stimulation, and Sacral Nerve Stimulation. Dr. Kilic manages all stages of patient care, from preoperative evaluation to postoperative follow-up. He focuses on achieving the best possible outcomes for his patients.
Dr. Kilic is an Associate Professor at Istinye University. He is active in neurosurgery research and education. As a member of the Turkish Neurosurgical Society, he has completed many advanced neuromodulation procedures. His work has led to high patient satisfaction and strong results in complex neurological cases.
Medical Area of Interest and Activities
Functional Neurosurgery (Parkinson’s, Deep Brain Stimulation)
Brain and Spinal tumors
Spinal degenerative diseases Education
Istanbul University Cerrahpaşa Faculty of Medicine
Trakya University Faculty of Medicine Brain and Nerve Surgery
Education
Istanbul University Cerrahpaşa Faculty of Medicine
Trakya University Faculty of Medicine Brain and Nerve Surgery
Experience
Ankara Gülhane Military Medical Academy Brain and Nerve Surgery
Osmaniye State Hospital
Bolu State Hospital
Private Taksim German Hospital
Taksim Training and Research Hospital
Istanbul University Faculty of Medicine Brain and Nerve Surgery
Liv Hospital Ulus
Memberships
Turkish Neurosurgery Society
Turkish Medical Association
Research and Publications
Development of micro-neurosurgery laboratory training model for orbita and optical nerves on fresh lamb cadaver (2007) •
Effect of Astaxanthin on NMDA sub units and MRNA expression levels in Primary Cortical Neurons
Articles in International Journals (18)
Chapters in International Books (1)
Articles in National Journals (5)
International Papers (12)
National Papers (24)
Dr. Burak Onvural is a board-certified microsurgeon in orthopedics and traumatology. He has over 17 years of clinical experience. He is known for his skills in treating sports injuries, joint replacements, and minimally invasive procedures such as knee and hip arthroscopy.
Dr. Onvural has worked as an orthopedic doctor for top sports clubs, including Altay FC in the Turkish Premier League. He has performed many successful surgeries, including anterior cruciate ligament reconstructions and stem cell therapies for arthritis. He received international training at the International Trauma Association in Switzerland. He is also accredited by leading orthopedic societies.
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Dr. Ilker Arslan is a specialist in prosthodontics and implantology. He is known for his skills in aesthetic dentistry. Dr. Arslan is a member of the Turkish Prosthodontics and Implantology Association (TPID), the International Team for Implantology (ITI), and the Turkish Academy of Aesthetic Dentistry (EDAD).
He is dedicated to ongoing training and follows international standards in dental care. His memberships show his commitment to new treatment methods and quality results for his patients in prosthodontics and implantology.
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Dr. Metin Kızılkaya is a specialist in Oral and Maxillofacial Surgery. He graduated from Istanbul University Faculty of Dentistry. He completed his doctorate at Başkent University, where he studied the effects of ibandronic acid on alveolar bone after tooth extraction. Dr. Kızılkaya has been practicing at Dent Suadiye since 2016.
He is a member of the Turkish Oral and Maxillofacial Surgery Society and the International Team of Implantology (ITI). Dr. Kızılkaya is dedicated to ongoing professional growth in implantology and surgical dentistry.
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Dr. Jaydeep Palep is a bariatric and upper GI surgeon with 17 years of experience. He specializes in minimally invasive and robotic weight loss surgeries. Dr. Palep is one of the first surgeons in India trained in Banded Bypass, Banded Sleeve Gastrectomy, and Mini Gastric Bypass. He has also received advanced training in Robotic GI Surgery in Italy and the USA.
Dr. Palep’s bariatric practice is certified as a Center of Excellence by the International Excellence Foundation (IEF). His practice has a morbidity rate of just 1%, which matches global standards. More than 90% of his diabetic patients stop using insulin and oral medications after surgery. He has published many articles in international journals and is invited to speak at conferences around the world.
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Personal Information
Name Surname : Serdar TOKER
Place of Birth - Year : Istanbul - 1972
Academic Title : Assoc. Dr.
Foreign Language : English
Education
Ege University Faculty of Medicine - Graduation
Sisli Etfal Training and Research Hospital - Specialised
Work Experience
1998 - 2003 Sisli Etfal Training and Research Hospital
2003 - 2004 Kars State Hospital
2004 - 2006 Erzurum Regional Training and Research Hospital
2006 - 2009 Dumlupınar University Faculty of Medicine, Department of Orthopaedics and Traumatology
2009 - 2010 Research Fellow. Colorado University Denver Healt Centre Rocky Mountain Regional Trauma Centre Department of Orthopaedics and Hand Surgery
2010 - 2016 Necmettin Erbakan University Department of Orthopaedics and Traumatology. Head of Hand Surgery Department
Courses - Seminars and Certificates Received
2013 FESSH (Federation of European Societies for Surgery of the Hand) European Diploma
2015 RMCD Microsurgery Course Course Chair
2015 National Turkish Orthopaedics and Traumatology Congress Speaker
2015 RMCD Congress Speaker
2014 National Turkish Orthopaedics and Traumatology Congress Speaker
2013 - 2014 Rıdvan Ege Hand Surgery Course Instructor
2013 RMCD Microsurgery Course Instructor
2013 RMCD Congress Session Chair
2012 Shoulder Elbow Surgery Course Instructor
2012 Subspeciality Diploma in Hand Surgery
2011 RMCD Microsurgery Course
2009 Ankle Arthroscopy Course
2008 Knee Arthroscopy Course
2005 Ilizarov Applications Course
Doctor: Kilis Merkez No. 1 Health Center, 2006-2008
Assistant Doctor: Mersin University Faculty of Medicine, 2009-2013
Specialist Doctor: Bingöl Genç State Hospital, 2013-2014
Minor Assistant: Akdeniz University Faculty of Medicine, 2014-2017
Minor Specialist: Erzurum Regional Training and Research Hospital, 2017-2018
Subspecialist: Gaziosmanpaşa Training and Research Hospital, 2018-2020
Attending Specialist: Başakşehir Çam and Sakura City Hospital, 2020-2022
Associate Professor: Başakşehir Çam and Sakura City Hospital, 2023
Associate Professor: Istinye University Medicalpark Gaziosmanpaşa Hospital, 2023-2024
Turkish Pediatric Society
Turkish Society for Pediatric Gastroenterology Hepatology and Nutrition
ESPGHAN - European Society for Pediatric Gastroenterology Hepatology and Nutrition.
University of Wisconsin Clinic of Neurosurgery (2017, Madison/USA)
Bakırköy Psychiatric Hospital (2014, Istanbul/Turkey)
Mersin University Faculty of Medicine (2007, Mersin/Turkey)
Istanbul Kanuni Sultan Süleyman Training and Research Hospital (2014-2021, Istanbul/Turkey)
Istanbul Bakırköy Mental and Neurological Diseases Hospital (2008-2014, Istanbul/Turkey)
Çorlu State Hospital (2007-2008, Çorlu/Turkey)
Turkish Neurosurgical Society
Turkish Spine Society
EUROSPINE
Turkish Medical Association