Sheba Pediatric CAR-T Program for Primary CNS Lymphoma

• 血液内科相談
• リンパ腫診断
• 血液検査
• リンパ腫血液検査
• PET-CT検査
• センチネルリンパ節生検
• 複合腫瘍診断
• オンコヘマトロジー相談
• CAR-T細胞療法
• HIV抗体検査
• B型肝炎コア抗体検査
• 抗HCV抗体検査
• 血液検査
• 生化学血液検査
• 生検
• 胸部X線
• 全血球計算（CBC）
• 腫瘍専門医との診察
• 血液専門医へのコンサルテーション
• 免疫専門医への相談
• 小児血液専門医との相談
• 小児科医との相談
• 腫瘍マーカーおよび蛋白分画を含む全血球算定
• 心電図（ECG）
• 心エコー図検査
• 循環器科医への相談
• 頭部MRI
• PET/CT
• 腫瘍血液専門医との診察
• 24時間看護サービス
• 栄養士による1日3食

• 21 日 病院で

• 空港－クリニック－空港間の送迎

Sheba Pediatric CAR-T Program for Primary CNS Lymphoma

At Sheba Medical Center, children and young patients with primary central nervous system (CNS) lymphoma have access to one of the most advanced and specialized CAR-T therapy programs in the world. This rare and complex lymphoma, affecting the brain and spinal cord, requires highly precise and coordinated care, especially in relapsed or treatment-resistant cases.

A Personalized Treatment Designed for Each Patient

CAR-T therapy uses the patient’s own immune system to recognize and destroy cancer cells. For CNS lymphoma, this innovative approach offers a targeted option when conventional therapies are no longer sufficient.

At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality:

Apheresis – collection of the patient’s T-cells
Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
Infusion – reintroduction of modified cells to target lymphoma cells

Because no steps are outsourced, treatment can begin quickly and is typically completed within ~10 days. CAR-T acts as a “living therapy,” continuing to work in the body and offering the potential for long-term disease control.

Expert Pediatric Leadership and Multidisciplinary Care

The program is led by Prof. Amos Toren, a globally recognized expert in pediatric hemato-oncology and cellular therapies, with decades of experience and over 1,500 bone marrow transplants performed.

Given the complexity of CNS lymphoma, care is delivered through a multidisciplinary team, including pediatric hemato-oncologists, neurologists, neurosurgeons, and radiology experts.

The program includes:

Specialized pediatric CAR-T units with 24/7 monitoring
Advanced neuro-imaging and precision diagnostics
A supportive, family-centered environment
Full international patient services, including travel and care coordination
Proven Expertise in Complex and High-Risk Cases

Sheba is a global leader in CAR-T therapy, with strong outcomes across hematologic cancers:

~90% remission in pediatric patients
~80% in young adults (up to 23 years)
~70% in adults

The team has extensive experience in treating rare and high-risk conditions, including CNS involvement, offering advanced options when other treatments are limited.

Comprehensive Evaluation and Ongoing Support

Each patient undergoes a full diagnostic work-up, including:
advanced brain and spinal imaging (MRI/CT), bone marrow evaluation, genetic and molecular testing, and cardiac and pulmonary assessment.

Care is provided in English, Russian, and Arabic, ensuring families feel supported and informed throughout the entire journey.

A Trusted Place for Advanced Pediatric Neuro-Oncology Care

By combining cutting-edge immunotherapy, neurological expertise, and compassionate care, Sheba provides one of the most advanced environments for treating primary CNS lymphoma with CAR-T—focused on achieving the best possible outcomes and quality of life for every patient.

• 専任医療コーディネーター
• 医療旅行手配 — 特別パートナー価格での航空券・ホテル予約
• 医療旅行中の患者擁護